In this study, we investigated the antihuman lung cancer activity and growth inhibition mechanisms of hct in human lung cancer a549 cells. Saururaceae is an herbaceous perennial plant that grows in moist and shady places. It had been reported to have potential functions such as antibacterial, anticancer, and antiinflammatory in human. Abstractdevelopment of a therapy providing protection from, or reversing gentamicinsulfate gsinduced. Houttuynia cordata thunb promotes activation of hif1a. Genus houttuynia are rhizomatous perennials with pungently orangescented, heartshaped leaves and tiny yellow flowers in spikes with usually 4 prominent white bracts at the base. Enhance the immune system to help the body resist the diseases and prolong the patients life. There are many american herbs with similar properties including knotweed. Hc is a medicinal herb that generally used in traditional chinese medicine for treating allergic inflammation. This characteristic implies that the substitution or addition of free hydroxyl group at certain positions may culminate in a. Houttuynia cordata is a herbaceous perennial plant growing to between 20 and 80 cm. Their structures were elucidated by analysis of 1d and 2d nmr.
Houttuynia cordata thunb, a medical herb, has an inherent odor due to lauric aldehyde and homologs thereof contained therein. The status of the species and its variations in physiological performance in different habitats were studied in selected sites of geographically different areas of brahmaputra valley in eastern. This invention provides a method of removing said inherent odor from houttuynia cordata thunb which comprises subjecting green houttuynia cordata thunb to a heattreatment and then fermenting the thus heattreated houttuynia cordata thunb with yeast, koji or a. However, the potential anticancer activity and mechanism of h cordata for human liver cancer cells is not well understood. Antiasma, anti bakteri, mengobati influenza dan antiradang. Application has vernacular full name houttuynia name id b8b640a8415d460aa68f7fdafab7e91c according to nicol, e.
Houttuynia cordata in kew science plants of the world online. Increased flavonoid compounds from fermented houttuynia. However, it has not yet been reported to have an antiobesity effect. Research article antihyperglycemic activity of houttuynia. Pdf houttuynia cordata thunb inhibits the production of pro. Houttuynia cordata thunb is a famous traditional chinese medicine. To evaluate the in vitro activities of the ethyl acetate ea fraction of houttuynia cordata h.
Houttuynia cordata was first described by the swedish naturalist carl peter thunberg in his flora japonica in 1784 from material collected in japan. Effect of airdrying temperature on antioxidant activity of houttuynia cordata thunb. The record derives from wcsp data supplied on 20120326 which reports it as an accepted name record 385534 with original publication details. However, in breast cancer, their mechanisms responsible for anticarcinogenic effects have not been clarified yet. Houttuynia cordata, also known as fish mint, fish leaf, rainbow plant, chameleon plant, heart leaf, fish wort, chinese lizard tail, or bishops weed, is one of two species in the genus houttuynia the other being h. Structure of an antimicrobial substance isolated from. From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in china. Read gas chromatographymass spectrometry analysis of volatile compounds from houttuynia cordata thunb after extraction by solidphase microextraction, flash evaporation and steam distillation, analytica chimica acta on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A current update on the phytopharmacological aspects of.
Houttuynia cordata thunb inhibits the production of proinflammatory cytokines through inhibition of the nf. The proximal part of the stem is trailing and produces adventitious roots, while the distal part of the stem grows vertically. Functional uses cosmetic ingredient for skin conditioning. The expression of plant flavonoids is partly regulated by fermentation. Antiinflammatory functions of houttuynia cordata thunb. Houttuynia cordata thunb h cordata, a medicinal plant, has anticancer activity, as it inhibits cell growth and induces cell apoptosis in cancer. The cells were then incubated in glucose free dmem supplemented with 2% horse serum for 96 h until more than 90% differentiation was achieved approximately 96 h. Snh treatment with different concentrati rsc advances hot article collection. The aims of this study were to evaluate the antioxidative effect of a traditional taiwanese vegetable, houttuynia cordata thunb. Houttuynia cordata chameleon v heartleaved houttuynia. Saururaceae and three of its constituent flavonoids quercetin, quercitrin and rutin against murine corona.
They will prefer a partially shaded environment and will grow in shallow water or moist soil. Combined effect of dark and wounding on regeneration. Houttuynia cordata thunb hct is commonly used in taiwan and other asian countries as an antiinflammatory, antibacterial and antiviral herbal medicine. Recently, we identified hypoxiainducible factor hif1a, forkhead box foxo3, and mef2a as proapoptotic factors induced by. Saururaceae is well known as a traditional medicine plant and widely spread in china, japan and india. Houttuynia cordata is a rhizomatous perennial that typically grows 915 tall and spreads indefinitely and often vigorously by rhizomes. Severe acute respiratory syndrome sars is a lifethreatening form of pneumonia caused by sars coronavirus sarscov. In the study of the effects of houttuyniae herba, the aerial part of houttuynia cordata thunb.
Antiinflammatory effects of houttuynia cordata supercritical. The present study investigated the inhibitory effect of the volatile oil from hc thunb. Houttuyninum, an active constituent of chinese herbal medicine, houttuynia cordata thunb inhibited phosphorylation of her2 in a dosedependent manner with an ic50 of 5. Extraction and separation of flavonoids from houttuynia. It was first described by swedish researcher carl peter thunberg in 1784. Further the antioxidant potential of the extract was also evaluated to substantiate its hepatoprotective properties.
The leaves are alternate, broadly heartshaped, 49 cm long and 38 cm broad. However, a lack of available genomic information has become a limitation for research on this species. Houttuynoids ae 15, a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside 6 were isolated from the whole plant of houttuynia cordata. Definitions of terms are available in the gcw introduction. Udo seeds scarecely germinated immediately after harvesting and when they had been in dry storage, while seeds stored in the cold wet sand germinated well. A taxonomic species within the family saururaceae heartleaf or lizard tail, native to east asia. Houttuynia cordata thunb h cordata is a medicinal plant that is considered to have antiinflammatory and antiviral effects, 1 antiobesity effects, 2 and anticancer activity because it inhibits cell growth and induces apoptosis in human colorectal cancer, 3,4 leukemic cancer, 5 and lung cancer cells. This site uses cookies to analyze traffic and for ads measurement purposes. Houttuynia grows natively in wet, warm parts of china as well as nepal, india, japan, thailand and indonesia. Recently, it has been reported that the plantderived micrornamirna possibly transported from one species to another and exerted a cross. Houttuynia is a plant that also goes by its botanical name houttuynia cordata thunb and chinese name dokudami. Hepatoprotective effect of houttuynia cordata thunb.
Houttuynia cordata is also used in folk medicine for diuresis and detoxification and herbal medicine for its antiviral, antibacterial and antileukemic activities. It may become invasive so be prepared to give this species of perennial some room. Antiinflammatory effects of houttuynia cordata supercritical extract hse were investigated in rat carrageenanair pouch model. Transcriptome analysis of houttuynia cordata thunb. The microwaveassisted extraction technique for flavonoids from houttuynia cordata thunb. The board of trustees of the royal botanic gardens, kew. Assessment of availability, ecological feature, and. The plant is collected from natural habitats for local consumption and trade. Thunb is an important medicinal plant widely distributed in east asia. Therapeutic potentials of houttuynia cordata thunb. It is also common in the wetter and warmer parts of china, where it is valued for its many uses. Identification of microrna in houttuynia cordata thunb and. National plant germplasm system covid19 update, march 23, 2020.
An ethyl acetate fraction derived from houttuynia cordata extract inhibits the production of inflammatory markers by suppressing nfb and mapk activation in lipopolysaccharidestimulated raw 264. Houttuynia resembles english ivy, with red stems and bluegreen leaves somewhat metallic in appearance. Pr are common herbs that are widely distributed throughout east asia and possess various biological properties including anticancer effects. The present study was focused on the hepatoprotective effects of h. Synthesis of the substance was achieved from methyl nonyl ketone and ethyl formate by means of the claisen condensation. Immunomodulatory and antisars activities of houttuynia.
Chemical properties of an antimicrobial substance isolated from houttuynia cordata, a popular medicinal plant in eastern and southeastern asia, were investigated and it was found to contain decanoyl acetaldehyde. Hepes bu er, acid free were purchased from himedia mumbai and sodium succinate, sodium azide, phenazine methanesulphonate pms, and nitro blue tetrazolium were purchased from merck. Houttuynia cordata chameleon chameleon houttuynia as described herein, and practically the only form available, with multicolored foliage for full sun to partial shade conditons, also listed as houttuynia cordata variegata notes. Optimization of potassium for proper growth and physiological response of houttuynia cordata thunb. Houttuynia has become popular in the last few years. Actions as resistance in cancer and stop the growth of cancer cells. Houttuynia cordata variegata chameleon plant plant. Health benefits of houttuynia cordata medicinal uses of. A hypothetical biogenetic pathway for houttuynoids ae was proposed. This is a deciduous perennial which has aromatic leaves and will produces small sprays of white flowers in the summer. Weh also inhibited the oleic acid and glycerolinduced increase in the levels of plasma nonesterified. To investigate the inhibitory activity of houttuynia cordata thunb fractions hcfs on the t helper 2 th2 immune response, we evaluated the alternation of the release of th2type cytokines and chemokines such as interleukin il4 and il5, and. Systematic analysis of components and contents in houttuynia cordata thunb. Houttuynia cordata wikibooks, open books for an open world.
Contents legal notices general notices monographs s. In vitro, snh exhibited a concentrationdependent cytotoxic effect against four human cancer lines hepg2, a2780, mcf7, skov3. Antiinflammatory activity of the dietary supplement. Houttuynia cordata thunberg hc is a flowering peren. Houttuynia cordata hc saururaceae has been used internally and externally as a traditional medicine. It is an aromatic medicinal herb belonging to family saururaceae and is restricted to specialized moist habitats. Files are available under licenses specified on their description page. All structured data from the file and property namespaces is available under the creative commons cc0 license. Oral administration of hse 50200 mgkg suppressed carrageenaninduced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose 200 mg kg. Frontiers pharmaceutical impact of houttuynia cordata. The lower stems trail along the ground and spread by producing adventitious roots, while the upright stems grow vertically to flower. The plant is well known among the people of diverse cultures across japan, korea, china and northeast india for its medicinal properties. Get pdf investigation of the chemical constituents of the essential.
Antitumor effect of volatile oil from houttuynia cordata. Houttuynia cordata thunb is an important medicinal plant widely distributed in east asia. Diabetes treatment a comprehensive study by kumar et al. Houttuynia cordata information from the global compendium of. Houttuynia is named after martin houttuyn, an 18th century dutch naturalist. Research article antihyperglycemic activity of houttuynia cordata thunb. It is primarily grown as a ground cover in moist to wet areas, including aquatic margins. Houttuynia cordata is a herbaceous perennial plant that can grow to 0. Presented here is summary information about the species houttuynia cordata from the global compendium of weeds, and citations of references to this species as a weed. The aim of this paper is to study the antitumor mechanism of volatile oil from houttuynia cordata thunb. Pdf effect of houttuynia cordata aetherolea on adiponectin. Us4331765a method of deodorizing houttuynia cordata. Saururaceae has long been used as a traditional herbal medicine.
Flavonoids, which form a major component in houttuynia cordata thunb. Houttuynia cordata thunb saururaceae is a traditional medicinal herb used to treat several disease symptoms. Evaluation of antiviral activities of houttuynia cordata. A perennial herb native to mountainous regions of eastern asia. Chemical constituents of volatile oil from houttuynia cordata thunb. The collected information is an attempt to cover recent developments in. During the past several decades, the medicinally important phytoconstituents have been identified including essential oil, flavonoids and other polyphenols, fatty.
This page was last edited on 26 october 2018, at 20. Houttuynia is a good herb but i am not completely up to date on its use for bartonella. Owing to the absence of definitive therapeutic western medicines, houttuynia cordata thunb. If you continue to use this site we will assume that you are happy with it. Hct that have been illustrated in the literature and to explore new fields in which hct could be used in the future. Effect of air drying temperature on antioxidant activity of houttuynia cordata thunb. At the same time,seven types of macroporous resin were selected to compare their performances in absorbing and desorbing flavonoids from houttuynia cordata thunb. It is been marketed as a creeping ornamental garden plant, which has heart shaped leaves up to 75mm long and almost as wide. In order to investigate effects of hct on a549 cells, mtt assay was used to evaluate cell viability. Therefore, we studied the effects of fermentation on h. Preventive effects of houttuynia cordata extract for oral infectious. Other common names heartleaved houttuynia chameleon. Houttuynia cordata thunb extract modulates g 0 g 1 arrest.
Basal part of stems creeping, rooted in whorls at nodes, apical part erect, glabrous or pubescent on nodes, sometimes purplish red. The leaves are comprised of a mixture of colours from green through yellow to red, the brighter colours being more prominent when grown in full sunlig. The record derives from wcsp data supplied on 20120326 which reports it as an accepted name record 385534 with. Taxon concept nzor concept id 45ea2af7ebaf46c2adf4cd62637b2d4d according to biosecurity new zealand 2008. Evaluation of antiviral activities of houttuynia cordata thunb. Recently it has been suggested that it might have antiobesity properties.
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